Royal Air Force Typhoon jets have conducted a mission with France's air force in a joint strike against an subterranean weapons facility in Syria employed by the IS group, according to the UK Ministry of Defence.
The facility, located using surveillance, was thought to be storing arms and explosives, the statement said, and was located in mountains just to the north of Palmyra in Syria's central region.
"The RAF jets used laser-guided Paveway IV weapons to hit a several entry passages leading to the site... early reports indicate the target was engaged successfully," the MoD said.
There was no evidence of any civilian casualties in the strike conducted Saturday night and every plane involved made a safe return, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as the so-called Islamic State - enforced extremist governance over significant areas in both Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates our UK leadership, and commitment to stand shoulder to shoulder with allied nations, to eradicate any resurgence of Daesh and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary stated.
RAF aircraft have performed patrols over Syria to "prevent any attempted resurgence" of Islamic State following its military defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I must thank the personnel of our armed forces involved in this operation for their professionalism and their bravery," he said. "Including them were a great many UK service members stationed over the holidays. This action, to take out terrorist threats who threaten our way of life, highlights how our armed forces are prepared to act, continuously, protecting the UK domestically and powerful internationally."
In December, the American forces carried out what it described as a "large-scale strike" on Daesh sites in Syria, after an attack claimed the lives of two American soldiers and a civilian interpreter in the Palmyra area.
The United Nations says Daesh still maintains roughly 5-7 thousand fighters in Syria and Iraq.